At the Centre for Intelligent Systems and their Applications (CISA) we enable computer systems to reproduce or complement human abilities, work with people, and support collaboration between humans. We conduct world-leading research in the foundations of Artificial Intelligence (knowledge representation and reasoning, emergence of meaning, theory and ontology change, creativity, mathematical proof) and in intelligent collaborative systems (multiagent systems, social computation, scientific collaboration platforms, web semantics and linked data). Our research methods are inspired by developing formal models of knowledge, reasoning, and interaction that can be used to understand and automate aspects of human intelligence, but are also understandable and usable to the human designers and users of AI systems. To achieve this, we combine theoretical research into computational models, architectures, and algorithms with a strong element of applied research. This has led to a strong track record in using our methods to address real-world problems in healthcare, scientific collaboration, social computing, emergency systems, transportation, engineering, aerospace and others.