Research in the Cancer Biology Unit (Pre-Clinical Oncology) is translational and involves strong collaborations with clinicians and industry. Current research areas include: use of reporter constructs for the imaging of key biological parameters within tumours, such as growth, apoptosis, angiogenesis and metastatic pathways and stem cell evolution; modelling the tumour microenvironment including the process of epithelial-mesenchymal transition; analysis of paracrine interactions in tumour progression including HGF/c-met, Hedgehog, and Fibroblast growth factors; delivery of siRNAs using non-viral and viral delivery systems for target validation; pre clinical validation/target identification of traditional Chinese medicines; and contribution of catenin controlled intestinal stem-cell associated homeodomain transcription factors to carcinogenesis and the involvement of the tumour suppressor gene, FBW7 a ubiquitin ligase, in intestinal malignant progression. The University of Nottingham is consistently named as one of the most targeted universities by Britain's leading graduate employers and can offer students a head-start when it comes to their career.