The Clinical Neurology Research Group's main interest is multiple sclerosis (MS). We investigated paradoxically shared signalling pathways for interferon type 1 (IFN), an MS treatment, and interleukin-12 (IL-12), a proinflammatory cytokine detrimental in MS. We showed that different factors modulate the pathway differently when activated by IFN and IL-12, and that MS patients have an intrinsic IFN signalling deficit. We showed that astrocytes can express and produce most elements of the IL-12 family of cytokines. The School of Medicine has world-class laboratory facilities, incorporating the latest technologies and specialist services. The Faculty of Medicine and Health Sciences Graduate Centre provides a formal training course which covers a variety of transferable skills targeted specifically at students studying within the faculty. The course is credit weighted with particular parts of the course being compulsory /obligatory. The University of Nottingham is consistently named as one of the most targeted universities by Britain's leading graduate employers and can offer students a head-start when it comes to their career.