Loughborough University is a top-ten rated university in England for research intensity (REF2014) and an outstanding 66% of the work of Loughborough’s academic staff who were eligible to be submitted to the REF was judged as ‘world-leading’ or ‘internationally excellent’, compared to a national average figure of 43%. In choosing Loughborough for your research, you’ll work alongside academics who are leaders in their field. You will benefit from comprehensive support and guidance from our Doctoral College, including tailored careers advice, to help you succeed in your research and future career. Osteoarthritis (OA) is a joint disorder which is predominantly found in elderly individuals (Lee et al., 2013), but has recently been linked to sports participation at high levels (Vannini et al., 2016). As a result, OA afflicts millions of individuals across the world resulting in impaired quality of life and increased health costs (Lee et al., 2013). While a number of risk factors have been associated with OA, the pathophysiology of this disease is currently in its infancy in particular the effects in which OA has upon skeletal muscle. Understanding what contributes to the pathophysiology of OA can be difficult to perform in human subjects and the use of animal models with OA has ethical implications. Therefore, the use of in vitro models could provide a useful tool for studying OA at the cellular and molecular level. In particular, the use of tissue engineered skeletal muscle models have been applied to investigating various aspects of skeletal muscle physiology (Player et al., 2014; Martin et al., 2017). The project will involve the use of established tissue engineered skeletal muscle models to characterise models of skeletal muscle OA and how interventions (e.g. nutritional, or exercise) affect skeletal muscle function and physiology at the molecular level in an in vitro model of OA.