This is a research-based course. Students receive training in scientific laboratory skills and methods appropriate to the PhD project. Students undertake a specific research project of 3-4 years duration, and submit a dissertation which is examined for the PhD. In principle, the research project can be in any area of interest to Principal Investigators based at the Metabolic Research Laboratories, at the Wellcome Trust-MRC Institute of Metabolic Science. Between them, groups encompass skills in genetics, cell biology, cell signalling, neuroendocrinology, bioenergetics, human and animal physiology, as well as experimental medicine and clinical trials. Graduate students at the Metabolic Research Laboratories also attend regular weekly seminars by local, national and international speakers, and are encouraged to attend appropriate training courses provided by the University Graduate School of Life Sciences to widen their experience further. Our students have opportunities to present their work at group meetings and seminars within the Metabolic Research Laboratories as well as at conferences and symposia. Students also organise a student symposium each year, which gives valuable experience in all aspects of organising a scientific meeting, including managing budgets, arranging catering, scheduling the day and marketing the event.